ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig gamma-1 chain C region, membrane-bound form

Intermolecular
Cysteine 107 of Immunoglobulin kappa constant and cysteine 102
Intramolecular
Cysteine 244 and cysteine 92
A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 102 of Ig gamma-1 chain C region, membrane-bound form (213 and 218 respectively in this structure).

Details

Redox score ?
88
PDB code
1kcr
Structure name
crystal structure of antibody pc283 in complex with ps1 peptide
Structure deposition date
2001-11-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
Immunoglobulin kappa constant
Peptide B name
Ig gamma-1 chain C region, membrane-bound form
Peptide A accession
P01837
Peptide B accession
P01869
Peptide A residue number
107
Peptide B residue number
102

Ligandability

Cysteine 107 of Immunoglobulin kappa constant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Ig gamma-1 chain C region, membrane-bound form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig gamma-1 chain C region, membrane-bound form between cysteines 244 and 92 (22 and 92 respectively in this structure).

Details

Redox score ?
nan
PDB code
1acy
Structure name
crystal structure of the principal neutralizing site of hiv- 1
Structure deposition date
1994-02-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01869
Residue number A
244
Residue number B
92
Peptide name
Ig gamma-1 chain C region, membrane-bound form

Ligandability

Cysteine 244 of Ig gamma-1 chain C region, membrane-bound form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Ig gamma-1 chain C region, membrane-bound form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 in protein B could not be asigned to a Uniprot residue.
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